Screening diagnostic biomarkers of OSCC via an LCM-based proteomic approach

Finding Diagnostic Biomarkers in Proteomic Spectra

In seeking to find diagnostic biomarkers in proteomic spectra, two significant problems arise. First, not only is there noise in the measured intensity at each m/z value, but there is also noise in the measured m/z value itself. Second, the potential for overfitting is severe: it is easy to find features in the spectra that accurately discriminate disease states but have no biological meaning. ...

The proteomic search for diagnostic biomarkers: lost in translation?

Surrogate Prognostic Biomarkers in OSCC: The Paradigm of PA28γ Overexpression

Carcinomas of the head and neck represent the sixthmost commonA homopolymer form of PA28γ interacts with both MDM2 and p53 proteins and facilitates their physical interaction, which promotes ubiquitinationand MDM2-dependent proteasomal degradation of p53, thus limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Elimination of endogenous PA28γ in human cancer cells h...

Proteomic Biomarkers of Atherosclerosis

SUMMARY: Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The "omics" tool are becoming very useful in the development of new biomarkers in cardiovascular diseases. Among them, proteomics is especially fitted to look for new protei...

Diagnosis of Fibromyalgia Syndrome: Potential Biomarkers and Proteomic Approach